Congratulations to Dr. Robin Lee and his lab on their recent publication in Nature Communications. 

Chemical perturbation of specific protein-protein interactions (PPI) is notoriously difficult, yet necessary when complete inhibition of a signaling pathway is detrimental to the cell. Here, the authors use a systems approach and identify two first in class small molecules that specifically inhibit TNF-induced NF-κB activation.

https://www.nature.com/articles/s41467-019-08802-0