Joseph Maggiore

  • 3rd Year Graduate Student

Dissertation Research

Developing advanced tissue engineering of kidney organoids in order to understand disease processes and mechanisms in acute and chronic kidney disease.

Dissertation Mentor

Dr. Neil Hukriede

Education & Training

  • University of Pennsylvania, BSE in Bioengineering

Representative Publications

Maggiore JC, LeGraw R, Przepiorski A, Velazquez J, Chaney C, Streeter E, Silva-Barbosa A, Franks J, Hislop J, Hill A, Wu H, Pfister K, Howden SE, Watkins SC, Little M, Humphreys B, Watson A, Stolz DB, Kiani S, Davidson AJ, Carroll TJ, Cleaver OJ, Sims-Lucas S, Ebrahimkhani MR, Hukriede NA. Genetically engineering endothelial niche in human kidney organoids enables multilineage maturation, vascularization and de novo cell types. (2023). Kidney International, manuscript submitted. Posted to bioRxiv.

Maggiore JC, Castiglione M, Sanders V, Shah A, Taylor L, Davidson A, Hukriede NA, Gough A, Schurdak M. Clinical concordance of in vitro, animal and human toxicology studies in the setting of acute kidney injury. (2023). Kidney International. Submitted.

Molinari L, Del Rio-Pertuz G, Priyanka P, Smith A, Maggiore JC, Kennedy H. Gomez J, Seymour CW, Kellum JA. Distribution of acute and chronic kidney disease across clinical phenotypes for sepsis. (2023). CHEST. Submitted

Pereira BMV, Zeng Y, Maggiore JC, Eng DG, Kaverina N, McKinzie SR, O’Connor C, Loretz CJ, Hukriede NA, Pippin JW, Wessely O, Shankland SJ. Early podocyte injury leads toa. Glomerular premature aging phenotype. (2023). American Journal of Physiology, Renal Physiology. Accepted.

Montalbetti N, Przepiorski A, Shi S, Sheng S, Baty C, Maggiore JC, Carattino M. Functional Characterization of ion channels expressed in kidney organoids derived from human induced pluripotent stem cells. (2022). American Journal of Physiology, Renal Physiology.

Kaverina N, Schweickart RA, Chan CG, Maggiore JC, Eng DG, Zeng Y, Perry HS, O’connor C, Pereira BMV, Theberge AB, Vaughan JC, Loretz CJ, Chang A, Hukriede NA, Bitzer M, Pippin JW, Wessely O, Shankland SJ. Inhibiting NLRP3 Signaling in Aging Podocytes Improves Their Life- and Health-span.2023 Aging. Accepted.

Velazquez J, LeGraw R, Moghadam F, Tan Y, Kilbourne J, Maggiore JC, Hislop J, Liu S, Cats D, Chuva de Sousa Lopes SM, Plaisier C, Cahan P, Kiani S, Ebrahimkhani MR. Gene regulatory network analysis and engineering directs development and vascularization of multilineage human liver organoids. (2021). Cell Systems.

Das S, Browne KD, Laimo FA, Maggiore JC, Haisaier H, Aguilar C, Ali ZS, Mourkioti F, Cullen DK, Pre-Innervated Tissue Engineered Muscle Promotes a Pro-Regenerative Microenvironment Following Volumetric Muscle Loss. (2019). Nature Communications Biology.

Maggiore JC, Burrell JC, Browne KD, Katiyar KS, Cullen DK. Tissue engineered axon‐based “living scaffolds” promote survival of spinal cord motor neurons following peripheral nerve repair. (2019). Journal of Tissue Engineering and Regenerative Medicine.