Katherine Shipman

  • 7th Year Graduate Student

Dissertation Research

The proximal tubule is the only segment of the nephron that can reabsorbed protein and normally, functions so efficiently that urine is protein free. Proteins that are not reabsorbed by the proximal tubule can be toxic and cause damage to more distal parts of the nephron. We know that the uptake of many proteins is mediated by receptors and that the cells can change the amount of protein uptake in response to stimuli. I’m working to develop a model of receptor sorting and recycling in proximal tubule cells. Understanding the regulation of protein reabsorption can guide future research in diseases that cause proximal tubule dysfunction.

Dissertation Mentor

Dr. Ora Weisz

Education & Training

  • B.S. in Biology, College of William and Mary, VA, 2015

Awards

  • American Society of Nephrology PreDoctoral Fellowship Award 2017-18
  • NIH NIDDK Pre-Doctoral Fellowship (F31), Megalin Traffic in Dent Disease, 2019-present
  • Experimental Biology Epithelial Transport Group Poster Award Finalist 2020

Representative Publications

Gliozzi, ML., Espiritu, EB., Shipman, KE., Rbaibi, Y., Long, KR., Roy, N., Duncan, AW., Lazzara, MJ., Hukriede, NA., Baty, CJ., Weisz, OA. Effects of proximal tubule shortening on protein excretion in a Lowe syndrome model. J Am Soc Nephrol 2020 Jan 31(1):67-83. PMC6934997

Long, KR., Shipman, KE., Rbaibi, Y., Menshikova, EV., Ritov, VB., Eshbach, ML., Jiang, Y., Jackson, EK., Baty, CJ., and Weisz, OA. Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTOR-dependent pathway. Mol Biol Cell 2017 Sep 28(19):2508-2517. PMC5597323.